TAT and Anxiety: In a variety of well-characterized animal behavior tests, chronic Tat exposure negatively affected motor, cognitive, and anxiety measures, in general agreement with outcomes after more acute exposure (Fitting et al. 2013; Carey et al. 2012, 2013), and mirroring cortical and subcortical functional deficits in HIV patients that affect both cognitive and motor skills (Woods et al. 2009; McArthur et al. 2010; Heaton et al. 2010).