Moreover, an increasing body of evidence has underlined the importance of aldosterone in cardiovascular complications associated with metabolic syndrome, such as arterial remodeling and endothelial dysfunction, and hence, MR blockade is increasingly being used as a form of evidence-based therapy for many forms of cardiovascular disease, including hypertension, heart failure, chronic kidney disease, and diabetes mellitus (DM) [9]. This evidence concerns the gene NR3C2 and diabetes mellitus.