Further, Satomi [44] has reported the role of fucoxanthin on the MAPKs (extracellular signal-regulated kinases ERK1/2, ERK5, p38 MAPK kinases, c-Jun N-terminal kinases (SAPK/JNK)) and its association with the GADD45 activation for cell growth arrest in LNCap cells (prostate cancer). The gene discussed is GADD45A; the disease is Familial prostate cancer.