However, in most instances, genetic defects, structural defects and/or the gene expression defects in IL-12/IL12R family members might be the causing issues for the development of a variety of human cancers such as esophageal cancer [12], lung cancer [10], acute myeloid leukemia [13], oesophageal squamous cell carcinoma [14] and human chronic B cell malignancies [15]. This evidence concerns the gene IL12RB1 and cancer.