Our results showed that the overall frequency of TKIs sensitive EGFR mutations was 33.7%, and the EGFR mutation rate in squamous-cell carcinoma (14.5%), adenocarcinoma (52.9%) and adenosquamous carcinoma (39.5%) was higher than the data from previous Asian population-based studies [2,6–9,13]. The gene discussed is EGFR; the disease is adenosquamous carcinoma.