EGFR and adenocarcinoma: Furthermore, a significant correlation was noticed between TKIs sensitive EGFR mutations and the clinical features of the female gender (p < 0.001), non-smoking history (p = 0.047) and adenocarcinoma subtype (p < 0.001), while patient age and tumor stage were not significantly associated with EGFR mutations (p = 0.060, p = 0.584 respectively).