Therefore, we combined the promoter methylation results for SFRP2, WIF-1, DKK3 and SOX17, in polypoid and nonpolypoid adenomas, with previously obtained molecular data on APC mutation [13], APC methylation (Voorham et al., submitted) and chromosome 5q loss [14] in the same samples. The gene discussed is SFRP2; the disease is adenoma.