DKK3 and adenoma: Interestingly, DKK3 and WIF-1 methylation frequencies were significantly higher in polypoid adenomas (DKK3; 97% (38/39), WIF-1; 87% (34/39)) compared to nonpolypoid adenomas (DKK3; 76% (32/42), WIF-1; 57% (24/42); p = 0.005 and p = 0.003, respectively).