In this study, we successfully constructed an immune escape inhibition system (Figure 1A), which was afforded by the construction of the recombinant expression plasmid pGM-CSF-GFP-IRES- Rae-1-IL-21 that passed RT-PCR and gene sequencing analyses to augment host immunity and proteins that are expressed by tumor cells and then recognized by host immune cells. The gene discussed is RAE1; the disease is neoplasm.