CSF2 and acute promyelocytic leukemia: The multipotent promyelocytic leukemia cell line HL60 can be stimulated to differentiate into neutrophils using different chemical agents like including granulocyte macrophage colony-stimulating factor (GM-CSF) [26], DMSO [27], all-trans-retinoic acid (ATRA) [28], 1,25-dihydroxyvitamin D3 [29], and 12-O-tetradecanoylphorbol 13-acetate (TPA) [30].