As described in our previous study [12], the top functions of differentially expressed genes illustrated the three main cellular events known to be involved in early follicular development: the change in the shape of the GC cell from flattened to cuboidal (IPA categories “cell movement”; “shape change of tumor cell lines”: 30 genes including FLNB, EDNRA), the marked increase in the number of GCs (x 40 in sheep species up to the secondary stage) and oocyte enlargement [17] (x 300 between the primordial and antral stages: IPA category “morphology of germ cells”: 31 genes including ASZ1, TDRD5). The gene discussed is EDNRA; the disease is neoplasm.