In breast cancer, the role of miR-126 in tumor metastasis may be related to the negative regulation of insulin receptor substrate-1 expression and it inhibits endothelial cell recruitment and angiogenesis through the negative regulation of IGFBP2/IGF1/IGF1R and GAS6/ MERTK signaling pathways [17]. This evidence concerns the gene IGFBP2 and breast carcinoma.