In the last years, we have demonstrated that different molecules such as soluble (s)HLA-G, ICAM-1, cytoplasmic melanoma-associated antigen (CYT-MAA), and high-molecular weight melanoma associated antigen (HMW-MAA) were more abundant in NB patients' plasma than in healthy children [4, 5]. This evidence concerns the gene HLA-G and neuroblastoma.