The differential expression of TNFRs in ACR and ccRCC provides a therapeutic rationale for developing drugs that target individual receptors rather than targeting global TNF, which might not yield the desired results as this would affect both TNFRs, where TNFR1 signalling is detrimental in ACR while TNFR2 is beneficial, but detrimental in ccRCC. The gene discussed is TNFRSF1A; the disease is nonpapillary renal cell carcinoma.