Moreover, in ccRCC organ cultures, the downstream effects of TNFR2 signaling occur at much lower concentrations of TNF compared to TNFR1 signalling, consistent with in vitro data [80] whereby TNFR2 contribute to the effects of low concentrations of TNF, possibly serving to capture and pass TNF to the less abundant signalling (TNFR1) receptor. This evidence concerns the gene TNFRSF1A and nonpapillary renal cell carcinoma.