The absolute TNFR2 dependence of cell cycle entry in malignant TECs in ccRCC organ cultures using wild type TNF and a TNFR2-selective mutein (but not TNFR1-selective mutein) clearly supports an active signalling rather than a ligand-passing function of TNFR1 [16]. Here, TNFRSF1B is linked to nonpapillary renal cell carcinoma.