In case of breast cancer (BC), different serum markers were tested for these purposes, and to date, the most used in clinical practice are carcinoembryonic antigen (CEA), the soluble form of MUC-1 protein (CA15-3), circulating cytokeratins such as tissue polypeptide antigen (TPA), tissue polypeptide specific antigen (TPS) and cytokeratin 19 fragment (CIFRA-21-1), and the proteolytically cleaved ectodomain of the human epidermal growth factor receptor 2 (s-HER2). This evidence concerns the gene ERBB2 and breast cancer.