CEACAM5 and colonic neoplasm: Indeed, overexpression of CEA and CEACAM6 inhibits anoikis and apoptosis in colon and pancreatic cancer cells [12], disrupts cell polarization and tissue architecture [13], enhances liver metastasis [13], increases chemoresistance [14] as well as recombinant overexpression of CEACAM5 and -6 proteins in transgenic mice (CEABAC mice), and promotes the formation of colon tumours and lung tumours [15].