The early-onset FECD may be associated with mutations in the COL8A2 gene, encoding the α2 subtype of collagen VIII [20], whereas late-onset FECD may be associated with mutations in the SLC4A11 gene, which encodes a zinc finger transcription factor and the TCF8 gene encoding sodium borate transporter [21–23]. This evidence concerns the gene COL8A2 and Fuchs endothelial corneal dystrophy.