IL10 and infection: The nature of immune response is also influenced by environmental factors such as the presence of environmental mycobacteria which prime Th1 type responses, whereas infection with soil transmitted helminths induces Th2 type responses and stimulates T-regulatory cells which secrete anti-inflammatory cytokines such as interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) [22, 23].