As a member of the leucine zipper family of DNA binding proteins, CREB1 (cAMP responsive element binding protein 1) may play an important role in the dopaminergic activation of c-fos in the striatum, and the lacking of a CREB1-induced transcription cascade may contribute to long-lasting psychomotor disorders in PD [35]. This evidence concerns the gene CREB1 and Parkinson disease.