SNCA and Parkinson disease: For example, miR-7 and miR-153 are recently described to regulate endogenous synuclein levels; inhibition of α-synuclein expression by miR-7 protects against oxidative stress-mediated cell death [7, 8]; several studies suggest that the role of LRRK2 in the pathogenesis of PD is mediated through the miRNA pathway [9].