The RB tumor suppressor gene is commonly deleted in human retinoblastoma, osteosarcoma, and small cell lung carcinoma, but other genes upstream in the RB pathway, including p16/INK4A (CDKN2A) and Cyclin D1 (CCND1) are more commonly deregulated in human cancer than the RB tumor suppressor gene itself (366, 367). The gene discussed is CCND1; the disease is osteosarcoma.