In total, 3.5% of the transcriptome is regulated by PARP-1 with 60–70% positively regulated (76), including genes involved in tumor promotion such as JUND, MDM2, HGF, FLT1 (VEGFR1), EGFR, HIF2A (EPAS1), SPP1 (OPN), MMP28, ANGPT2, and PDGF (77). This evidence concerns the gene PARP1 and neoplasm.