In total, 3.5% of the transcriptome is regulated by PARP-1 with 60–70% positively regulated (76), including genes involved in tumor promotion such as JUND, MDM2, HGF, FLT1 (VEGFR1), EGFR, HIF2A (EPAS1), SPP1 (OPN), MMP28, ANGPT2, and PDGF (77). The gene discussed is EPAS1; the disease is neoplasm.