TNFRSF11B and ischemic stroke: Recently, three polymorphisms (T245G, T950C and G1181C) in the OPG gene, which are reported to be associated with increased serum OPG levels, were found more frequently in patients with carotid plaques (Straface et al. 2011) or in diabetic patients with a history of ischemic stroke (Biscetti et al. 2013).