In population-based cohort studies, increased OPG levels were found to be associated with the future risk of myocardial infarct, ischemic stroke, and CV mortality (Kiechl et al. 2004; Vik et al. 2011; Mogelvang et al. 2013; Abedin et al. 2007). The gene discussed is TNFRSF11B; the disease is myocardial infarction.