Low expression of GnT-V may contribute to altered biological properties of bladder cancer as well as non-small cell lung cancer and hepatocellular carcinoma by decreasing the synthesis of β1-6 branching oligosaccharides of certain target glycoproteins, resulting in shorter survival in patients having tumors with low GnT-V expression compared with patients having tumors with high GnT-V expression (Akita2004; Ishimura et al.2006; Ito et al.2001). The gene discussed is MGAT5; the disease is hepatocellular carcinoma.