Since EGFR regulates fundamental cellular processes, it is not surprising that misregulation of EGFR signaling occurs frequently in several types of tumors including glioblastoma (GBM), colorectal cancer (CRC), head and neck squamous cell carcinoma (HNSCC), non-small cell lung cancer (NSCLC), breast, renal, ovarian, bladder, prostate and pancreatic cancers3-.5 This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.