Newman et al. maps of significant genes are the best indicators of gene expression heterogeneity within AMD's phenotypes and the difficulty in declaring any as global biomarkers; the vast majority of their claimed globally significant genes (Newman et al., Figure  2) are actually insignificant except for LOC100294179 in retina that is significant in dry AMD, GA, and CNV, and C10orf18 in RPE-choroid that is significant in CNV and MD. Here, TASOR2 is linked to dry age related macular degeneration.