The expression of CD73 and its ectonuclease activity producing adenosine have been proposed to be important in the functionality of Tregs (72) and recently the role of adenosine signalling was demonstrated to have a beneficial effect in AKI, as it was shown that the pre-treatment of dendritic cells with adenosine receptor 2 (A2R) agonist protected kidneys from ischemia/reperfusion induced injury in mice (73). This evidence concerns the gene NT5E and acute kidney injury.