TNF and neoplasm: The results showed that tumor-infiltrating NK cells from mice treated with CTLA4Ig possessed significantly higher cytolytic activity than those treated with control IgG (Figure 3A, from 44.2±4.2% vs 60.7±4.3%, p=0.007), but there were no significant differences in IFNγ and TNFα production in NK cells between the CTLA4Ig group and control IgG group (Figure 3B).