The clinical implications of these findings range from a deep understanding of the mechanism of Periostin in physiological conditions to the potential pharmacological intervention of Periostin in diseases and conditions like congenital ocular pathologies, persistent fetal vasculature [55], idiopathic pulmonary fibrosis [56], periodontal disease [57], and ventricular rupture after myocardial infarction [58] among others. This evidence concerns the gene POSTN and periodontal disorder.