LMNA and Emery-Dreifuss muscular dystrophy: Since Bonne et al. identified the first LMNA gene mutation in patients affected with autosomal dominant Emery-Dreifuss muscular dystrophy (EDMD), dilated cardiomyopathy (DCM) and conduction defects in 1999 [27], mutations in LMNA have subsequently been identified in individuals with isolated DCM, usually with a conduction defect [28].