To explore the mechanisms of miR-126 in the regulation of EPC EndMT, we confirmed that the gene coding for PI3K regulatory subunit p85 beta (PIK3R2), a target gene of miR-126 identified previously in endothelial cells [16], is also the target gene of miR-126 in EPCs by using a luciferase reporter assay, consistent with the findings in circulating EPCs in preeclampsia[25]. The gene discussed is PIK3R2; the disease is preeclampsia.