Forced expression of Lin28 in MCF-7 cells (pc-Lin28-1 and pc-Lin28-2 cells) remarkably increased the number of cancer cells that adhered to a fibronectin-coated surface by 13- and 12-fold as compared with vec MCF-7 cells, respectively (Figure 3A, p < 0.01), whereas the functionally dead Lin28 mutant had decreased numbers of adherent cells at levels that were comparable to those observed in the parent cells or vec MCF-7 cells (p > 0.05). The gene discussed is FN1; the disease is cancer.