When further confirming the post-transcriptional regulation of EMT by the RAN binding protein, we found that overexpression of Lin28 in breast cancer cells remarkably decreased the expression of the epithelial marker E-cadherin and increased the expression of the mesenchymal marker vimentin in addition to promoting significant changes in cell morphology toward a mesenchymal phenotype, suggesting that Lin28 induced the EMT in breast cancer cells. Here, CDH1 is linked to breast cancer.