VCX3A and Cognitive impairment: For instance, chromosomal rearrangements involving VCXA (variable charge x linked protein A), a protein modulating mRNA decapping and thus, mRNA stability and translation [4], have been connected with cognitive deficits (CDs), whereas point mutations affecting the protein were not found in patients with CDs yet [5,6], implying that alterations in the expression of VCXA are causing the impairments.