The factors significantly correlated with OS and EFS by univariate analyses were the age of patients, tumor stage, depth of tumor, lymph node metastasis, distant metastasis, histological grade, tumor differentiation, mitotic count, tumor necrosis, intra-tumoral infiltration of PD1-positive lymphocytes, PD-L1 expression, and the PD1/PD-L1 pattern (Figure 2) (Table 3). The gene discussed is CD274; the disease is neoplasm.