CD274 and cancer: Moreover, in addition to the prognostic indicative role of PD-L1 expression in human cancers, the expression of PD-L1 is important for the prediction of the efficacy of PD1-targeted immunotherapy; this is reflected in previous results which demonstrated that 36% of patients having PD-L1+ tumors responded to anti-PD1 immunotherapy, while patients with PD-L1- tumors did not [8].