APOE and permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome: The elevated serum apolipoprotein E levels in PaCa patients assessed in this initial study by 2D-DIGE and ELISA are in concordance with a recent study be Chen et al. Appling different approaches including ELISA they found an up-regulation of apolipoprotein E in PaCa-tissues and elevated apolipoprotein E levels in PaCa patients serum [40].