ADGRE1 and ischemic stroke: The data of present study showed that, at 24 h after MCAO, mRNA expression of microglial markers Cd68 and Emr1 in the peri-infarct cortical tissue was augmented, and the number of total microglia and the proportion of activated microglia were increased, suggesting that ischemic stroke results in microglial activation and proliferation in this brain area.