Parameters of the acute-phase response, particularly plasma IL-6 and C-reactive protein concentrations, are positively associated with stroke severity and infarct volume, and predict a higher risk of early clinical worsening [3,40].Thus, reductions in plasma proinflammatory cytokines IL-6 and C-reactive protein after treatment with propofol in our study are likely to reflect decreased risk of early clinical deterioration. This evidence concerns the gene CRP and Stroke.