Liu et al. [34] reported that clinical patients with acute lung injury constantly have increased plasma biomarkers such as plasminogen activator inhibitor-1, interleukin-6, and soluble tumor necrosis factor receptors after acute kidney injury, suggesting that disordered coagulation, inflammation, and neutrophil-endothelial interactions play important roles in the pathogenesis of acute kidney injury. This evidence concerns the gene SERPINE1 and injury.