Although the relationship between NBS1 mutations and TP53 pathway alterations is not statistical significant, probably due to a limited number of tumor cases analyzed, our data has provided a potential possibility for such relationship, with the p-value around the threshold, and with statistic significant result (p=0.0159) when cases with the NBS1 mutations which are predicted to be damaging to Nbs1 function were analyzed. This evidence concerns the gene TP53 and neoplasm.