TARDBP and Primary lateral sclerosis: These findings are in keeping with pathological studies showing that ubiquitin inclusions in PLS occurr in the frontotemporal cortex [33], [34], and that phosphorilated TDP-43 immunohistochemistry reveals the presence of many positively stained neuronal cytoplasmic inclusions as well as dystrophic neuritis/neuropil threads in the frontotemporal cortex and subcortical nuclei of these patients [33].