Melanoma cell adhesion molecule (MCAM/cd146/MUC18) is a component of a “Wnt-Receptor-Actin-Myosin-Polarity (W-RAMP)” structure that mediates polarity and protrusion retraction [79], and was previously identified on a uropod-like structure for WM239a melanoma cells in synthetic ECM [72]. This evidence concerns the gene MYH14 and melanoma.