Migrating GFP-MCAM WM239a cells were morphologically similar to rounded MDA-MB-231 breast carcinoma cells that were previously characterized by cortical F-actin flow towards a pronounced uropod-like structure [75,76] and A375 melanoma cells that expressed an “ezrin-rich uropod-like structure (ERULS) [74]. The gene discussed is EZR; the disease is melanoma.