CD8A and infection: Second, there could be a change in non-T cell immune components of the immune system such as the maturation of a vaccine-induced antibody response at the portal of viral entry that might help reduce the establishment and expansion of founder populations of infected cells, thereby creating an environment in which virus-specific CD8 T cells would be operating at numerically superior numbers compared to any infected targets in the early stages of infection at 20 weeks but not at 5 weeks.