In the Copenhagen City Heart Study [13], men aged >60 yrs had a 10-year prostate cancer risk of approximately 1.1%, if their PSA between 0.01 and 1.00 ng/mL and the risk was 3.6% for men with a PSA between 1.01 and 2.00 ng/mL. Here, KLK3 is linked to Familial prostate cancer.