[11], [12] This acute hyperglycemia impairs glomerular basement membrane, photoreceptor layer, inner plexiform layer and inner nuclear layer in adult zebrafish. It is further shown that larvae with hyperglycemia displayed altered cardiac development, [13] insulin and PEPCK expression. [14] Olsen et al. found that the fin regeneration was impaired in STZ induced hyperglycemia adult zebrafish. [12]. This evidence concerns the gene PCK2 and Hyperglycemia.