PNPLA3 and metabolic dysfunction-associated steatotic liver disease: It was reported that the minor allele of rs738409 C/G, a nonsynonymous coding single nucleotide polymorphism (SNP) in the PNPLA3 gene encoding I148M change, was associated with steatosis, portal inflammation, lobular inflammation, Mallory-Denk bodies, NAFLD activity score (NAS) and fibrosis [12].