The K688A mutation in dynamin 2, which in human dynamin 1 (L694A) greatly impairs self-assembly in vitro and in vivo[39], [40], [41], [42], produced only a minimal rescue of invadosome formation (Fig. 4A) No rescue was produced by the pleckstrin homology (PH) domain K562E mutant of dynamin 2 that corresponds to a centronuclear myopathy patient mutation [43]. This evidence concerns the gene PLEK and autosomal dominant centronuclear myopathy.