RARA and acute promyelocytic leukemia: Cytogenetically, between 95 and 100% of APL cases have been reported to be associated with karyotypic abnormalities involving pathognomonic translocations at t(15;17)(q22–24;q11–21) that juxtapose the retinoic acid receptor α (RARα) gene with the promyelocytic leukemia (PML) gene (6,7).