Among the 46 OSC samples, p-Akt occurrence was negatively associated with the degree of tumor differentiation (P<0.01) and statistical analysis also revealed that p-Akt prevalence was positively associated with lymphatic metastasis (r=0.334; P=0.023), since OSC tissue with lymphatic metastasis exhibited significantly higher p-Akt levels compared with metastasis-free OSC tissue. The gene discussed is AKT1; the disease is neoplasm.