ANXA2 has been revealed as a multifunctional protein in vitro and in vivo. ANXA2 is located on the cell surface and is involved in biological processes, including anti-inflammatory effects, exocytosis, immune responses and phospholipase A2 regulation and is important for cell malignant transformation and progression for tumour invasion and metastases (19,20). Here, ANXA2 is linked to neoplasm.