In particular, severe hepatitis had the highest hALR level, which was 15-fold that of normal serum and 6 to 7-fold that of common hepatitis; the hALR level in acute hepatitis was 3-fold that of normal serum, and cirrhosis and chronic hepatitis had 3-fold higher serum hALR levels than normal serum. Here, KMT2C is linked to chronic hepatitis.