It was reported that NF-κB results in insulin resistance by activating proinflammatory cytokines like TNF-α, IL-6, IL-1β, and resistin, which consequently activates the c-Jun N-terminal kinase (JNK) and NF-κB pathways to create a vicious cycle that exacerbates tissue damage [70]. The gene discussed is IL6; the disease is Insulin resistance.