We previously reported that treatment with Corni Fructus for 10 days suppressed hyperglycemia, proteinuria, renal AGE formation, and related protein expressions, that is, receptor for AGEs (RAGE), nuclear factor-kappa B (NF-κB), transforming growth factor-β1 (TGF-β1), and Nε-(carboxymethyl)lysine (CML), in the same way as with aminoguanidine. The gene discussed is NFKB1; the disease is Hyperglycemia.