APS has been reported as a negative regulator of key ER stress indicators such as phosphorylated protein kinase-like endoplasmic reticulum kinase (PERK), activating transcription factor-6 (ATF-6), glycogen synthase kinase 3 beta (GSK3β), and XhoI site-binding protein 1 (XBP1) in type 2 diabetes models. The gene discussed is ATF6; the disease is type 2 diabetes mellitus.