While, Ad-Cre infection significantly inhibited the Icariin-induced expression of BMP2 (Figure 7(a)), BMP4 (Figure 7(b)), ALP (Figure 7(c)), and OC (Figure 7(d)), Ad-Cre-mediated deletion of the β-catenin gene was demonstrated by the reduction of β-catenin mRNA (Figure 7(e)) and protein (Figure 7(f)) expression in these cells. This evidence concerns the gene BMP4 and infection.