In alloxan-induced diabetes rats, streptozotocin- (STZ-) induced rats models, and STZ-nicotinamide-induced rats models [14], oral administration of various dosages of curcumin (80 mg/kg·body weight (BW) for 21 days [15] and 45 days [16]; 60 mg/kg·BW for 14 days [17]; 90 mg/kg·BW for 15 days [18]; 150 mg/kg·BW for 49 days [19]; 300 mg/kg·BW for 56 days [20]; 100 mg/kg·BW) for 4 weeks [21], 7 weeks [22], and 8 weeks [23] were able to prevent body weight loss, reduce the levels of glucose, hemoglobin (Hb), and glycosylated hemoglobin (HbA1C) in blood [15], and improve insulin sensitivity [16]. The gene discussed is GSTM1; the disease is diabetes mellitus.