Concluding, the present study revealed two aspects: (1) a part of naive CHC patients has blood serum iron markers within the normal range; however, the percentage of those with advanced liver fibrosis is high and is significantly correlated to serum levels of iron, ferritin and TIBC; (2) even though the iron markers do not differ significantly in patients with low or high HCV viremia, serum ferritin and transferrin levels seem to play an important role to determine the severity of liver disease, related both to the liver fibrosis and necroinflammatory activity. Here, TF is linked to liver disorder.